Septemper 2023 Volume 9 Issue 3

MEDICAL SCIENCES JOURNAL

Evaluating the Microbiological Profile of Urinary Tract Infections in Males at a Tertiary Care Centre, Uttar Pradesh

Nashra Afaq,R. Sujatha

  • Pages: 1-12

Antimicrobial Resistance: A Comprehensive Review of Mechanisms, Burden, and Control Strategies

R. Sujatha,Nashra Afaq

  • Pages: 1-4
    • <p>Antimicrobial resistance (AMR) has emerged as a major global public health concern, threatening the effective prevention and treatment of infectious diseases. The increasing prevalence of resistant microorganisms has resulted in higher morbidity, mortality, and healthcare costs worldwide. This review aims to comprehensively analyze the mechanisms, epidemiology, contributing factors, clinical impact, and current strategies to combat AMR. A structured literature review was conducted using major databases to identify relevant studies published in recent years. The findings highlight that misuse and overuse of antimicrobials, poor infection control practices, and lack of new drug development are key drivers of resistance. Multidrug-resistant organisms such as MRSA, carbapenemresistant Enterobacteriaceae, and Acinetobacter baumannii have significantly increased in both hospital and community settings. Strengthening antimicrobial stewardship programs, enhancing surveillance, promoting infection prevention measures, and encouraging research into novel therapeutics are essential steps in combating AMR. Coordinated global efforts are urgently needed to address this growing threat.</p>

TO STUDY THE PREVALENCE OF URINARY TRACT INFECTION AND THE MOLECULAR CHARACTERIZATION WITH SPECIAL REFERENCE TO FIM H GENE IN UROPATHOGENIC E. COLI ISOLATED FROM URINE SAMPLES AT A TERTIARY CARE

Nashra Afaq, R. Sujatha

  • Pages: 1-22

Nanoparticle-Based Therapeutic Strategies against Staphylococcus aureus: A Comprehensive Review

Nashra Afaq,R. Sujatha

  • Pages: 1-4
    • <p>Staphylococcus aureus is a major human pathogen responsible for a wide spectrum of infections ranging from superficial skin infections to life-threatening conditions such as sepsis, endocarditis, and pneumonia. The emergence of multidrug-resistant strains, particularly methicillin-resistant Staphylococcus aureus (MRSA), has posed a significant global healthcare challenge. Nanotechnology has emerged as a promising alternative strategy for combating antimicrobial resistance. Nanoparticles (NPs), including metallic, polymeric, lipid-based, and hybrid nanostructures, exhibit potent antibacterial activity through multiple mechanisms such as membrane disruption, reactive oxygen species (ROS) generation, and targeted drug delivery. This review summarizes the types of nanoparticles used against S. aureus, their mechanisms of action, synthesis methods, in vitro and in vivo efficacy, and clinical potential. Additionally, challenges such as toxicity, scalability, and regulatory concerns are discussed. Nanoparticles represent a novel and effective therapeutic approach that may overcome current antibiotic resistance issues.</p>
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